نوع مقاله : مقاله پژوهشی
عنوان مقاله English
نویسندگان English
Hyperthermia using magnetic nanoparticles offers a non‑invasive approach for prostate cancer treatment. Since invasive temperature measurement in tumors is challenging, computational models like Pennes bioheat transfer equation are required. The novelty lies in simultaneous investigation of magnetic and electric fields on fractional viscoelastic blood flow within a stenosed vessel not previously modeled. Using COMSOL, Navier‑Stokes, energy, and concentration equations were solved to examine effects of field amplitude/frequency, volume fraction (0.02, 0.04, 0.06), and particle diameter on velocity, temperature, and concentration. Results show increasing nanoparticle concentration or field amplitude enhances heat generation. Each unit increase in induced heat flux raises prostate temperature by 0.2 °C, enabling precise titration to therapeutic window (41–45 °C) while protecting adjacent tissues (rectum, urethra) from necrosis. Raising inlet velocity from 0.1 to 0.2 m/s increases wall shear stresses; at volume fraction 0.04, pressure drop across stenosis rises 25% relative to baselin. A serious hemodynamic alert for elderly cardiovascular patients, highlighting need for personalized dosing and monitoring. The proposed framework provides a predictive tool for personalized dosage and field optimization in prostate cancer hyperthermia.
کلیدواژهها English
